PART
A
Title : Sieving
Objectives
1. To
determine the size and size distribution of a particular powder.
2. To
classify and differentiate the powders based on their diameter.
Date of Experiment :
20 November 2014
Introduction
Sieving are most frequently used to break down
agglomerates and determine the size and size distribution of a particular
powder. In this experiment, sieve nest was used to determine the particle size
and the size distribution of both powders.
sieve nest
Procedure
1. 100g of lactose was weighed.
2. The sieve
nest was prepared in descending order, from the largest to the smallest
diameter, from
top to bottom.
3. The lactose
powder was placed at the uppermost sieve and allow the sieving process to
proceed
for 10minutes.
4. When the
sieving process already completed, the powder in each sieve was collected and
weighed. A particle size distribution histogram was plotted.
5. The process
was repeated by using MCC.
MCC powder
Result
Discussion
Sieving
is a method used to assess the particle size distribution of a granular material or powders. Sieving can be performed
on any type of organic or non-organic
granular materials and for this experiment, we were using lactose and MCC
powders. At the beginning of this experiment, 100g of lactose and MCC was poured into the
sieve nest and undergo sieving process for 10 minutes.
After the process finished, the
weight of lactose and MCC are 99.88g and 98.90g respectively. The weight for both powders after the sieving
process finished is slightly less than the initial weight. From this result, it
shows that there is a loss of powders during the sieving process. This loss is
due to some of the powders particles are still stuck in the woven sieve cloth.
Based on the histogram, the
highest amount of lactose powders collected at the sieve with the range of
200≤x<300mm, which is 53.56% of
the lactose. Followed by 24.08% of lactose at sieve within the range of
150≤x<200mm and lastly at the range of 50≤x<150mm with 22.01% of lactose powders. However for MCC powders, the highest amount of these
powders were remained at the sieve range less than 50mm which consist of 58.63% of the MCC powders and
followed by 34.00% of MCC powders at sieve with range 50≤x<150mm. There is a different
between the result due to differences in physical properties of both powders.
Questions
1.What
are the average particle size for both lactose and MCC?
The average particle size for both
lactose and MCC are 45µm and then
followed by <50µm, between 50 – 150 µm, between 150 – 300 µm, between 300 –
425 µm and lastly >500
2.What
other methods can you use to determine the size of particle?
3.What
are the importance of particle size in a pharmaceutical formulation?
The important
physical characteristic of material used in order to create pharmaceutical
products is particle size distribution of active ingredients and excipients. Bulk
properties, product performance, processability, stability and appearance of
the end product is affected by the size, distribution and shape of the
particles. Particle size and product
influence are closely linked to dissolution, absorption rates and content
uniformity so it can achieve
optimum production of
efficacious medicines especially in pharmaceutic
phase.
Conclusion
Sieveing is one the process to determine the size of
a particle. The particle size is quite important in pharmaceutical industry.
Hence, the distribution size of a
particle can be analysed after conducting this experiment.
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